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Nuclear Medicine Adenosine, Persantine or Lexiscan Test

This test simulates exercise and increases blood flow to the heart by using the drugs Persantine, Adenosine or Lexiscan. To obtain images, a small injection of radioactive tracer is used which circulates in the bloodstream and shows if your heart muscle is receiving adequate blood supply under exercise and/or rest conditions. The radioactive tracer Myoview is a clear liquid and is not a dye.

Is a Persantine, Adenosine or Lexiscan Test Safe?

Any stress procedure may have some risks, and you should consult with your physician regarding the risks and benefits of this procedure. Myoview, Persantine, Adenosine or Lexiscan are all safe with low incidence of adverse reactions and are used routinely worldwide, under physician supervision, for Myocardial Perfusion Imaging.

Why Would My Doctor Order a Nuclear Medicine Test With Persantine, Adenosine or Lexiscan?

This drug-simulated test is designed for patients who need exercise testing but are unable to exercise on a treadmill. This form of testing improves diagnostic accuracy by showing 3-dimensional heart images, heart movement and pumping data.

How is the Test Performed?

The entire test may be completed using a one or two-day protocol. For the one-day protocol, the rest portion will be done first, and then the exercise portion will be done. For the one-day protocol, the rest portion will be done first, and then the "simulated exercise" will follow. For the two-day protocol, the rest portion and the exercise portion will be done on separate days. A special camera detects Myoview. We take two sets of images, one set of "rest" images, and one set of "exercise" images after receiving Persantine or Adenosine. For imaging, you will lie down on a special table while the camera rotates above and around your chest. It is very important that you lie still with normal breathing and be able to keep your left arm above your head for the 20 minute imaging sessions.

For the rest study, Myoview will be injected in an IV line, which is placed in your hand or arm. After waiting about 20 minutes, images of your heart will be taken.

For the simulated exercise, EKG electrodes will be attached to your chest and a blood pressure cuff placed on your arm. This will allow your physician to monitor your heart rate and blood pressure before, during, and after the simulated exercise.

Persantine, Adenosine or Lexiscan will be injected into your IV line over a period of about 4 minutes. During this time you may feel some chest pressure, a headache or shortness of breath — like you would normally feel while exercising. This is a normal response to the drug and will quickly pass.

Also, we often inject the drug Aminophylline to stop the symptoms and action of the exercise drug. Myoview will be injected into the IV line at a prescribed time during the "exercise" drug infusion. After waiting at least 20 minutes, the final set of images will be taken. The camera will rotate over you for approximately 20 minutes.

Important Points to Remember

  • The radioactive material is ordered especially for you and for a specific time. If you are unable to keep your appointment for any reason, notify the office within 24 hours before the exam or you may be charged for the drug.
  • You must be able to keep your left arm over your head for 20 minutes.
  • A written report of the test will be sent to your physician once it is interpreted.
  • If you are breast-feeding, pregnant, or suspect that you may be, notify your doctor. The test cannot be performed.
  • The test will take about 3 hours.
  • For two-day protocol tests, remember to return for the second part.
  • If you use an inhaler, please bring it with you to this appointment.
  • Only patients are allowed in the imaging center unless the patient needs to bring in an adult to interpret.


Please read and follow these instructions very carefully!

  1. NO COFFEE or TEA 24 hours before the test. This includes any caffeinated or decaffeinated beverages. You may have a small amount of water. DO NOT EAT 4 HOURS prior to the test. (If you are a diabetic, you may eat a small snack and use your insulin as usual.)
  2. Do not take your aspirin the day of the test.
  3. Wear comfortable clothing, suitable for continuous exercising, and comfortable walking or running shoes.
  4. Do not use any type of body lotion on the day of the test. Deodorant is okay.
  5. Do not smoke or use any type of tobacco on the day of the test.
  6. Do not take your Beta-Blockers 24 hours prior to test. HOLD your calcium-channel blockers and nitrates for 24 hours prior to test. (These medications are listed below.) Otherwise take all your medications as usual.
  7. Bring your medications so that you can resume them as soon as testing is complete.

HOLD Beta Blockers 24 HOURS


CORGARD (Nadolol)

COREG (Carvedilol)

LOPRESSOR (Metoprolol)

INDERAL (Propranolol)

SECTRAL (Acebutolol)

NORMODYNE (Labetalol)

TOPROL (Metoprolol)

TENORMIN (Atenolol)

VISKEN (Pindolol)

TRANDATE (Labetalol)

ZIAC (Bisoprolol/HCTZ)

ZEBETA (Bisoprolol)



HOLD Calcium Channel Blockers 24 HOURS

ADALAT (Nifedipine)

CALAN (Verapamil HCL)

CARDENE (Nicardipine HCL)

CARDIZEM (Diltiazem)

COVERA (Verapamil)

DYNACIRC (Isradipine)

DILACOR (Diltiazem)

NIMOROP (Nimodipine)

ISOPTIN (Verapamil)

PROCARDIA (Nifedipine)

PLENDIL (Felodipine)

TIAZAC (Diltiazem)

SULAR (Nisoldipine)

VASCOR (Bepridil)


HOLD Nitrates 24 HOURS

IMDUR (Isosorbide mononitrate)

ISORDIL (Isosorbide mononitrate)

ISMO (Isosorbide mononitrate)





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